BDBM50344069 CHEMBL1777862::rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-ynoic acid

SMILES CC#CC(CC(O)=O)c1ccc(Oc2ccc(cc2Cl)C#N)cc1

InChI Key InChIKey=FGWIQWCSFPANHU-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50344069   

TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataEC50:  597nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataEC50:  519nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed