BDBM50343767 (S)-1-(2-Cyanoethyl)-3-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea::CHEMBL1774356

SMILES C[C@H]1COCCN1c1nc(nc2c1COC2(C)C)-c1ccc(NC(=O)NCCC#N)cc1

InChI Key InChIKey=MRSNNKTWHOYIHT-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343767   

TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343767((S)-1-(2-Cyanoethyl)-3-(4-(7,7-dimethyl-4-(3-methy...)
Affinity DataIC50: 26nMAssay Description:Inhibition of mTor in human NCI-PC3 cells assessed as inhibition of Akt phosphorylation at serine473 by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343767((S)-1-(2-Cyanoethyl)-3-(4-(7,7-dimethyl-4-(3-methy...)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTOR in human NCI-PC3 cells assessed as inhibition of p70S6k phosphorylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343767((S)-1-(2-Cyanoethyl)-3-(4-(7,7-dimethyl-4-(3-methy...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed