BDBM50343750 1-Ethyl-3-(4-((R)-7-(2-methoxyethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea::CHEMBL1774374

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2c(CO[C@]2(C)CCOC)c(n1)N1CCOC[C@@H]1C

InChI Key InChIKey=QPZOGYGGPPCZSA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343750   

TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343750(1-Ethyl-3-(4-((R)-7-(2-methoxyethyl)-7-methyl-4-((...)
Affinity DataIC50: 69nMAssay Description:Inhibition of mTOR in human NCI-PC3 cells assessed as inhibition of p70S6k phosphorylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343750(1-Ethyl-3-(4-((R)-7-(2-methoxyethyl)-7-methyl-4-((...)
Affinity DataIC50: 41nMAssay Description:Inhibition of mTor in human NCI-PC3 cells assessed as inhibition of Akt phosphorylation at serine473 by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343750(1-Ethyl-3-(4-((R)-7-(2-methoxyethyl)-7-methyl-4-((...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed