BDBM50343532 4-(4-methyl-N-octylphenylsulfonamido)benzoic acid::CHEMBL1774311

SMILES CCCCCCCCN(c1ccc(cc1)C(O)=O)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=CLEASTWYNXZUOL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50343532   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 (DE3) using arachidonic acid as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate assessed as reduction in 5-LO product formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed