BDBM50343128 2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide::CHEMBL1771456

SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc3OCOc3c2)c1

InChI Key InChIKey=DLXNCEJKEWNGNI-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343128   

TargetP2Y purinoceptor 14(Mouse)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50343128(2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50343128(2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o...)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [35S]MK-0499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetP2Y purinoceptor 14(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50343128(2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o...)
Affinity DataKi:  160nMAssay Description:Antagonist activity at human recombinant P2Y14 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed