BDBM50343084 CHEMBL1771219::N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)propoxy)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide

SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(OCCCc2nc(no2)-c2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=VCIBNYPUVKINDS-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343084   

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  31nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  180nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  410nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed