BDBM50343078 CHEMBL1771213::N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide

SMILES COc1ccc(cc1)C(=O)N1CCN(CC1)c1ccc(cc1)S(=O)(=O)C1(CCOCC1)C(=O)NO

InChI Key InChIKey=QCRPOQONCVCBFI-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343078   

TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed