BDBM50342988 CHEMBL1770999::N4-isopropyl-N4-methyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

SMILES CC(C)N(C)c1cc(nc(N)n1)N1CCN(C)CC1

InChI Key InChIKey=JPNMLUHEKASEQE-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50342988   

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50342988(N4-isopropyl-N4-methyl-6-(4-methylpiperazin-1-yl)p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50342988(N4-isopropyl-N4-methyl-6-(4-methylpiperazin-1-yl)p...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed