BDBM50342751 CHEMBL1771485::N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydrazinecarbonyl)benzamide

SMILES ONC(=O)c1cccc(c1)C(=O)N\N=C\c1ccc(OCC#C)cc1

InChI Key InChIKey=ZNPSDGQOVMWWIJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50342751   

TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed