BDBM50342742 4-(3,5-Difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide::CHEMBL1771275

SMILES Fc1cc(F)cc(c1)-c1ccnc(c1)C(=O)Nc1cc(nn1-c1ccccc1Cl)-c1ccccc1

InChI Key InChIKey=YXFCIGALVQFZGC-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50342742   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50342742(4-(3,5-Difluorophenyl)-N-(1-[2-chlorophenyl]-3-phe...)
Affinity DataEC50:  646nMAssay Description:Agonist activity at rat mGluR5 expressed in HEK293T cells assessed as effect on glutamate-induced calcium flux by calcium fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50342742(4-(3,5-Difluorophenyl)-N-(1-[2-chlorophenyl]-3-phe...)
Affinity DataKi:  344nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed