BDBM50342590 (E)-4-chloro-3-(2-oxo-2-(pyridin-3-yl)ethylidene)-1-phenylindolin-2-one::CHEMBL1770529

SMILES Clc1cccc2N(C(=O)\C(=C\C(=O)c3cccnc3)c12)c1ccccc1

InChI Key InChIKey=MAXLUMXHDRQNGJ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342590   

TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342590((E)-4-chloro-3-(2-oxo-2-(pyridin-3-yl)ethylidene)-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342590((E)-4-chloro-3-(2-oxo-2-(pyridin-3-yl)ethylidene)-...)
Affinity DataIC50: 570nMAssay Description:Inhibition of human transglutaminase 2 using ZGBC as a substrate after 30 to 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342590((E)-4-chloro-3-(2-oxo-2-(pyridin-3-yl)ethylidene)-...)
Affinity DataKi:  9.10E+3nMAssay Description:Non-competitive inhibition of recombinant human TG2 V224 mutant deamidation activity using Cbz-Gln-Gly as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed