BDBM50342210 4-(5-Phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide::CHEMBL1766287

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1

InChI Key InChIKey=CSEPEVFNTFMBAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50342210   

TargetBifunctional epoxide hydrolase 2(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342210BDBM50342210(4-(5-Phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ure...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342210BDBM50342210(4-(5-Phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ure...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant COX-2 after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Texas at Austin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342210BDBM50342210(4-(5-Phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ure...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKR1C3 in human COLO 205 cells by Cell based AKR activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Texas at Austin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342210BDBM50342210(4-(5-Phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ure...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of AKR1C3 (unknown origin) in human HEK293T cells assessed as turnover of coumberone to coumberol by live cell coumberone reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed