BDBM50341986 6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)-2-phenylbenzofuran-5-carboxylic acid::CHEMBL1765367

SMILES OC(=O)c1cc2c(-c3cn(CC(=O)Nc4ccc(cc4)N4CCOCC4)nn3)c(oc2cc1O)-c1ccccc1

InChI Key InChIKey=XDUPIYKMBPUQSZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341986   

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis full-length N-terminal His6-tagged PTPB expressed in Escherichia coli BL21 DE3 using pNPP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in Escherichia coli using pNPP as substrate measured after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of full length Mycobacterium tuberculosis His6-tagged ptpB expressed in Escherichia coli BL21(DE3) using pNPP as substrate measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Huanghuai University

Curated by ChEMBL
LigandPNGBDBM50341986(6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoe...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of TC-PTP (unknown origin) expressed in Escherichia coli using pNPP as substrate measured after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed