BDBM50341804 (1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrazino[1,2-a]-benzimidazole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylicAcid::CHEMBL1767006

SMILES C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)N1CCn2c(C1)nc1ccc(F)cc21)C(O)=O

InChI Key InChIKey=HTBWAVKWLNLFGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341804   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341804((1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrazino[...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341804((1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrazino[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341804((1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrazino[...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MMP1 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341804((1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrazino[...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant TACE after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed