BDBM50341733 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766779::US10479784, Compound I-82::US10961232, Compound I-82

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1

InChI Key InChIKey=DUIHHZKTCSNTGM-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50341733   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 26nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50341733(3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed