BDBM50341493 CHEMBL1765463::Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]-pyridine-3-carboxylate

SMILES CCOC(=O)c1cnc2ccc(cn12)-c1cncc(NS(=O)(=O)c2ccccc2)c1

InChI Key InChIKey=SEKOTFCHZNXZMM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341493   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3Kalpha after 180 mins by luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 59nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by HTRF colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 87nMAssay Description:Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 104nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3Kgamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50341493(Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by Kinase-Glo plus luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed