BDBM50341410 CHEMBL4166144::US11534443, Example 1

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1cc(OC2CCOCC2)c2nc(N)nc(C)c2c1

InChI Key InChIKey=FEHPMLVVSQNYOF-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50341410   

TargetCytochrome P450 2E1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) using FAM-labeled peptide as substrate by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as reduction in acetaminophen formation using phenacetin as substrate after 10 to 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1 peptide as substrate after 30 mins by Lance Ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cell membranes by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextrophan formation using detromethorphann as substrate after 10 to 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4-Hydroxydiclofenac formation using diclofenac as substrate after 10 to 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1-Hydroxymidazolam formation using midazolam as substrate after 10 to 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as reduction in 4-Hydroxymephenytoinn formation using mephenytoin as substrate after 10 to 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110alpha/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.800nMAssay Description:The Kinase-Glo Kinase Assay Kit was purchased from Promega. All assays were performed at room temperature using white OptiPlate -384 well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent