BDBM50341356 6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2-tetrazol-2-ylethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one::6-(2,4-difluorophenoxy)-8-methyl-2-{[(1S)-1-methyl-2-(2H-tetrazol-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1232784

SMILES C[C@@H](Cn1ncnn1)Nc2ncc3c(n2)N(C(=O)C(=C3)Oc4ccc(cc4F)F)C

InChI Key InChIKey=WIGNNIARPGHXFO-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50341356   

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341356(6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Zagreb

Curated by ChEMBL
LigandPNGBDBM50341356(6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)