BDBM50341247 (2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-5-ethyl-2-morpholinecarboxamide::CHEMBL1765744

SMILES CC[C@@H]1CO[C@@H](CN1c1cc(nc(NC)n1)-c1ccc2c(N)n[nH]c2c1)C(=O)NC1CCCCC1

InChI Key InChIKey=XXCHHDLPUJYVJU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341247   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 102nMAssay Description:Inhibition of PDK1-mediated RSK phosphorylation at Ser221 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341247((2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 85nMAssay Description:Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed