BDBM503412 (4M)-2-(4-amino-4-methylpiperidin-1- yl)-5-(2-chloro-4-fluoro-3- methoxyphenyl)-6-methylpyrimidine-4- carboxamide::US11033547, Compound 115::US11033547, Compound 116::US11696916, Compound 116

SMILES COc1c(F)ccc(c1Cl)-c1c(C)nc(nc1C(N)=O)N1CCC(C)(N)CC1

InChI Key InChIKey=QVABOPWURJBUEO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 503412   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503412(US11033547, Compound 116 | (4M)-2-(4-amino-4-methy...)
Affinity DataIC50: 570nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503412(US11033547, Compound 116 | (4M)-2-(4-amino-4-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503412(US11033547, Compound 116 | (4M)-2-(4-amino-4-methy...)
Affinity DataIC50: 570nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503412(US11033547, Compound 116 | (4M)-2-(4-amino-4-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent