BDBM50341081 (5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone::CHEMBL1760206

SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(-c2ccc(Cl)cc2)n(C)n1

InChI Key InChIKey=SFBJQTXZKXTYKE-UHFFFAOYSA-N

Data  5 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50341081   

TargetNeuromedin-K receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataKi:  370nMAssay Description:Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataKi:  370nMAssay Description:Binding affinity to human NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to human NK1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Rat)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity to rat NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341081((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to human NK2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed