BDBM50341063 2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methyl-1,3,5-triazin-2-ylamino)acetonitrile::CHEMBL1762782

SMILES Cc1nc(NCC#N)nc(n1)-n1c(Nc2cccc(O)c2)nc2ccccc12

InChI Key InChIKey=MOYOOFRKRSCAKY-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50341063   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 380nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 17nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 32nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  11nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  16nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  43nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341063(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  69nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed