BDBM50340925 CHEMBL1761931::Ethyl {4-[6,7-dimethoxy-quinazolin-4-ylamino]phenyl}carbamate (11c)::ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylcarbamate

SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1

InChI Key InChIKey=JVWYBRODEHTVBN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340925   

TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 4.79E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 8.12E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340925(ethyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylc...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed