BDBM50340921 CHEMBL1761927::N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)acetamide::N-{4-[6,7-Dimethoxy-quinazolin-4-ylamino]phenyl}acetamide (11a)

SMILES COc1cc2ncnc(Nc3ccc(NC(C)=O)cc3)c2cc1OC

InChI Key InChIKey=VYDHNVNGKIOQFA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50340921   

TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 3.13E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.47E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Rat)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50340921(N-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed