BDBM503408 2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2-chloro-3-trifluoromethyl- phenyl)-6-methyl-pyrimidine-4- carboxylic acid amide::US11033547, Compound 111::US11696916, Compound 111

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(c1Cl)C(F)(F)F)N1CCC(C)(N)CC1

InChI Key InChIKey=STCLIZYTGXCNDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503408   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503408(2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2-chloro-3...)
Affinity DataIC50: 530nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503408(2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2-chloro-3...)
Affinity DataIC50: 530nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent