BDBM50340725 CHEMBL1668584::N,5,7-trimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidin-2-amine::US8829009, 1.1(1)

SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=YPVOSIDECMYMTD-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340725   

Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataIC50: 5nMAssay Description:Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2015
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataIC50: 5.13E+3nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.257nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.260nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  1.04E+3nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed