BDBM503406 (5P)-6-amino-2-[(4R)-4-amino-4- methylazepan-1-yl]-5-(2,3- dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 109::US11696916, Compound 109

SMILES C[C@@]1(N)CCCN(CC1)c1nc(N)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl

InChI Key InChIKey=AURKNQJDGSCBLL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503406   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503406((5P)-6-amino-2-[(4R)-4-amino-4- methylazepan-1-yl]...)
Affinity DataIC50: 71nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503406((5P)-6-amino-2-[(4R)-4-amino-4- methylazepan-1-yl]...)
Affinity DataIC50: 71nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent