BDBM50340371 3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761312

SMILES CCS(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C

InChI Key InChIKey=HDJZSGDARWVVJV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340371   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed