BDBM503398 (5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- isoindol-2-yl]-6-amino-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11033547, Compound 101::US11033547, Compound 103::US11696916, Compound 103

SMILES NC[C@@]12CN(C[C@@H]1CCCC2)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=IKMGLAPRJVWUEO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 503398   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503398(US11033547, Compound 103 | (5P)-2-[(3aS,7aR)-3a- (...)
Affinity DataIC50: 75nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503398(US11033547, Compound 103 | (5P)-2-[(3aS,7aR)-3a- (...)
Affinity DataIC50: 5.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503398(US11033547, Compound 103 | (5P)-2-[(3aS,7aR)-3a- (...)
Affinity DataIC50: 75nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503398(US11033547, Compound 103 | (5P)-2-[(3aS,7aR)-3a- (...)
Affinity DataIC50: 5.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent