BDBM50339667 4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)benzyl]oxy}-2Hchromen-2-one::CHEMBL1688892

SMILES FC(F)(F)c1cccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)c1

InChI Key InChIKey=ABYADXYJTVWBHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50339667   

TargetAromatase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339667(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)...)
Affinity DataIC50: 235nMAssay Description:Inhibition of human placental microsomal CYP19 using [1beta-3H]androstenedione substrate pre-incubated for 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339667(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh11B1 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339667(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh11B2 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339667(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)...)
Affinity DataIC50: 235nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed