BDBM50339643 4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxybenzyl)oxy]-2H-chromen-2-one::CHEMBL1688899

SMILES FC(F)(F)Oc1ccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc1

InChI Key InChIKey=ZAHRTXYUTYHLLU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50339643   

TargetAromatase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339643(4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxyb...)
Affinity DataIC50: 481nMAssay Description:Inhibition of human placental microsomal CYP19 using [1beta-3H]androstenedione substrate pre-incubated for 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339643(4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxyb...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh11B1 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339643(4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxyb...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh11B2 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339643(4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxyb...)
Affinity DataIC50: 481nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed