BDBM50339635 1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea::CHEMBL1688888

SMILES Cc1nn(C)c2ncc(cc12)C(=O)NC(=O)Nc1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=WOMTXGGBILJJNX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50339635   

TargetC-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR4 in transfected in THP-1 cells assessed as inhibition of CCL17-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CXCR1 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CXCR2 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at CCR2 in mouse spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed