BDBM50339608 3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688861

SMILES CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1

InChI Key InChIKey=GXEGTVQATHKFDH-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50339608   

TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) preincubated for 20 mins followed by addition of 2 microM Biotin-DRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 56nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cell line assessed as inhibition of ERK phosphorylation for 3 hrs with compound by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human ERG using tracer red fluorescent probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 170nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 42nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 7nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 190nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed