BDBM503395 (5P)-2-[(3aR,6aS)-3a- (aminomethyl)-octahydro- cyclopenta[c]pyrrol-2-yl]-6-amino-5- (2,3-dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 98::US11033547, Compound 99

SMILES NC[C@@]12CCC[C@@H]1CN(C2)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=OYZALVSWJSKCSW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503395   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503395(US11033547, Compound 99 | (5P)-2-[(3aR,6aS)-3a- (a...)
Affinity DataIC50: 49nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503395(US11033547, Compound 99 | (5P)-2-[(3aR,6aS)-3a- (a...)
Affinity DataIC50: 3.70E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent