BDBM503391 (5P)-2-[(3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5]-decan-8-yl]- 5-(2,3-dichloro-phenyl)-6- methylpyrimidine-4-carboxamide::US11033547, Compound 94::US11033547, Compound 95::US11696916, Compound 95

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(-c3cccc(Cl)c3Cl)c(n2)C(N)=O)[C@@H]1N

InChI Key InChIKey=SCCZIRSIZZLTSR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 503391   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503391(US11033547, Compound 95 | (5P)-2-[(3S,4S)-4-amino-...)
Affinity DataIC50: 2.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503391(US11033547, Compound 95 | (5P)-2-[(3S,4S)-4-amino-...)
Affinity DataIC50: 22nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503391(US11033547, Compound 95 | (5P)-2-[(3S,4S)-4-amino-...)
Affinity DataIC50: 48nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503391(US11033547, Compound 95 | (5P)-2-[(3S,4S)-4-amino-...)
Affinity DataIC50: 2.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503391(US11033547, Compound 95 | (5P)-2-[(3S,4S)-4-amino-...)
Affinity DataIC50: 22nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent