BDBM503386 (4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3- dichlorophenyl)-6- methylpyrimidine-4-carboxamide::US11033547, Compound 88::US11033547, Compound 89::US11696916, Compound 89

SMILES Cc1nc(N[C@@H]2CCC[C@H](N)C2)nc(C(N)=O)c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=QIPGUJJZESIZDZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 503386   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503386((4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3-...)
Affinity DataIC50: 410nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503386((4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3-...)
Affinity DataIC50: 1.30E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503386((4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3-...)
Affinity DataIC50: 410nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503386((4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3-...)
Affinity DataIC50: 1.30E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent