BDBM50338365 (-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl)-2-methyl-1H-benzo[e]isoindol-3(2H)-one::CHEMBL1682904

SMILES CC(C)[C@@](O)(c1cnc[nH]1)c1ccc2c3CN(C)C(=O)c3ccc2c1

InChI Key InChIKey=UCYQUZAJMGMKEU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338365   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338365((-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 19nMAssay Description:Inhibition of 17,20 lyase activity in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338365((-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSteroid 11-beta-monooxygenase(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338365((-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 11-hydroxylase activity in Sprague-Dawley rat adrenal glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338365((-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338365((-)-(S)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed