BDBM50338304 (+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol::CHEMBL1682438

SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(c(F)c12)-c1cccc2cc[nH]c12

InChI Key InChIKey=XRYJPXTUVITKHR-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50338304   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338304((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Affinity DataIC50: 19nMAssay Description:Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338304((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Affinity DataIC50: 3.80nMAssay Description:Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338304((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338304((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Affinity DataKi:  5nMAssay Description:Displacement of radiolabeled Dexamethasone from GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed