BDBM50337913 (+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine::CHEMBL1684055::CHEMBL1684059::N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine::US10562878, Compound 55

SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1

InChI Key InChIKey=DIOWQSMFSBKMCS-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50337913   

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 61nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 61nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 72nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 72nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent