BDBM50337911 (+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylethanamine::1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylethanamine::CHEMBL1684047::CHEMBL1684058::US10562878, Compound 43

SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=OBWKCACUZGJXHN-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50337911   

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 64nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 36nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
School of Medicine of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 64nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
School of Medicine of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
School of Medicine of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
School of Medicine of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337911(CHEMBL1684058 | CHEMBL1684047 | 1-(1-(3,4-dichloro...)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed