BDBM50337735 CHEMBL1615187::N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl}sulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide::US10322143, Compound 8m

SMILES C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2c(C)noc2C)CC1)N(O)C=O)c1ncc(F)cn1

InChI Key InChIKey=UAGAABCJKYADIR-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50337735   

LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 23nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of recombinant human MMP14 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 250nMAssay Description:Inhibition of TACE assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant human MMP1 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of recombinant human MMP2 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of recombinant human MMP13 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 2.51E+7nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 0.690nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 0.260nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent