BDBM50337733 CHEMBL1683444::N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)pentan-2-yl)-N-hydroxyformamide::US10322143, Compound 2

SMILES C[C@@H](C[C@@H](CS(=O)(=O)N1CCC(CC1)OCc1ccc(Cl)cc1Cl)N(O)C=O)c1ncc(F)cn1

InChI Key InChIKey=BGUXTVRZPYKBBN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50337733   

TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human MMP14 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human MMP13 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of recombinant human MMP1 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337733(N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1...)
Affinity DataIC50: 1nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent