BDBM50337732 CHEMBL1683452::N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperidin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl)-N-hydroxyformamide::US10322143, Compound 8d

SMILES C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2cc(F)ccc2Cl)CC1)N(O)C=O)c1ncc(F)cn1

InChI Key InChIKey=JAPLGNWCNXCEJT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50337732   

TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human MMP14 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human MMP2 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant human MMP13 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of recombinant human MMP1 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50337732(N-((2S,4S)-1-(4-(2-chloro-5-fluorophenethyl)piperi...)
Affinity DataIC50: 2.80nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
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