BDBM50337378 2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrimidin-3-amine::CHEMBL1682553

SMILES CC(C)Nc1c(nc2ncccn12)-c1ccc2[nH]ncc2c1

InChI Key InChIKey=DYSRECIVMDGUQU-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50337378   

TargetGlycogen synthase kinase-3 beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi:  17nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi:  65nMAssay Description:Inhibition of Rock2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi:  242nMAssay Description:Inhibition of Pim1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi: >1.80E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi: >3.75E+3nMAssay Description:Inhibition of Pak4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi:  4.34E+3nMAssay Description:Inhibition of aurora 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337378(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Affinity DataKi: >8.88E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed