BDBM50336921 3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-2-yl)-N-(6-methylpyridin-3-yl)pyridin-2-amine::CHEMBL1672539

SMILES CCCn1c(nc2cccc(Cl)c12)-c1cnc(Nc2ccc(C)nc2)c(Cl)c1

InChI Key InChIKey=RGKVPYQYBUAAEH-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50336921   

TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]ABP688 from human recombinant mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ABP688 from mGlu5 receptor in rat brain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed