BDBM50336867 CHEMBL1672315::N-(2-morpholino-6-(pyridin-3-yl)pyrimidin-4-yl)quinolin-3-amine

SMILES C1CN(CCO1)c1nc(Nc2cnc3ccccc3c2)cc(n1)-c1cccnc1

InChI Key InChIKey=DSFFUGFEBSCYPD-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50336867   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336867(N-(2-morpholino-6-(pyridin-3-yl)pyrimidin-4-yl)qui...)Copy SMILESCopy InChI

Affinity DataIC50: 135nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/23/2011
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336867(N-(2-morpholino-6-(pyridin-3-yl)pyrimidin-4-yl)qui...)Copy SMILESCopy InChI

Affinity DataEC50:  650nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/23/2011
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL