BDBM50336865 CHEMBL1672328::N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyrimidine-2',6-diamine

SMILES COc1ccc(Nc2cc(nc(n2)N2CCOCC2)-c2cnc(N)nc2)cn1

InChI Key InChIKey=XZTYTIOLZIKUJR-UHFFFAOYSA-N

Data  6 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50336865   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 92nMAssay Description:Inhibition of PI3Kbeta after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
8/23/2011
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Inhibition of PI3Kgamma after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
8/23/2011
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
8/23/2011
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TargetPhosphatidylinositol 4-kinase beta(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PI4Kbeta after 15 minsMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
8/23/2011
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TargetSerine/threonine-protein kinase mTOR(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mTOR after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
8/23/2011
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of VPS34 after 15 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
8/23/2011
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataEC50:  90nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/23/2011
Entry Details Article
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