BDBM50336806 1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-yl)piperazine-2,5-dione dihydrochloride::CHEMBL1672113

SMILES CC(C)Cc1nc2ccc(cc2c(-c2ccc(C)cc2)c1CN)N1CC(=O)NCC1=O

InChI Key InChIKey=VHNILDKAFINLSQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50336806   

TargetDipeptidyl peptidase 4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rat kidney Dipeptidyl peptidase-2 using H-Lys-Ala-pNA.2HCl as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of FLAG-tagged human Dipeptidyl peptidase-8 expressed in 293-F cells using Gly-Pro-pNA.Tos as substrate after 90 mins by microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of FLAG-tagged human Dipeptidyl peptidase-9 expressed in 293-F cells using Gly-Pro-pNA.Tos as substrate after 90 mins by microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of DPP4 in human Caco2 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed