BDBM50336590 3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1672082

SMILES Nc1ccc(Sc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1

InChI Key InChIKey=FNSJVQXUTIKAPS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50336590   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336590(3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]py...)
Affinity DataIC50: 5nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336590(3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]py...)
Affinity DataIC50: 302nMAssay Description:Displacement of FAM-Bid from human recombinant Bcl-2 after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336590(3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]py...)
Affinity DataIC50: 291nMAssay Description:Binding affinity to N-terminal 8xHis tagged cBcl-XL (unknown origin) expressed in Escherichia coli BL21 (DE3) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336590(3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]py...)
Affinity DataIC50: 331nMAssay Description:Binding affinity to human Bcl-2 (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336590(3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]py...)
Affinity DataIC50: 90nMAssay Description:Binding affinity to cMcl-1 (residues 171 to 327) (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed