BDBM50336588 3-(4-tert-amylthiophenol)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1672080

SMILES CCC(C)(C)c1ccc(Sc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1

InChI Key InChIKey=HFPAJOBPOFBWTH-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50336588   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336588(3-(4-tert-amylthiophenol)-8-oxo-8H-acenaphtho[1,2-...)
Affinity DataIC50: 585nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336588(3-(4-tert-amylthiophenol)-8-oxo-8H-acenaphtho[1,2-...)
Affinity DataIC50: 342nMAssay Description:Displacement of FAM-Bid from human recombinant Bcl-2 after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336588(3-(4-tert-amylthiophenol)-8-oxo-8H-acenaphtho[1,2-...)
Affinity DataKi:  961nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed